Granulocyte-stimulating Colony Factor Neuroprotection for Thoracic Myelopathy
نویسندگان
چکیده
منابع مشابه
Granulocyte colony-stimulating factor.
In the background section of their abstract, Woei-Cherng Shyu and associates state that because granulocyte colony-stimulating factor (G-CSF) has anti-inflammatory and neuroprotective properties and the capacity to mobilize stem cells, it has the potential to be used in treatment of stroke. However, there are limited data about the effects of G-CSF on hemostasis. It has been suggested that G-CS...
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Granulocyte colony-stimulating factor was discovered during attempts to define the normal regulators present in cell supernatants that could induce terminal differentiation of the murine myeloid leukemic cell line WEHI-3B D+. The purification and subsequent cloning of both murine and human G-CSF allowed the normal functions of this molecule to be elucidated and indicated that it was a relativel...
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Experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, can be induced by immunization with a number of myelin antigens. In particular, myelin oligodendrocyte glycoprotein, a central nervous system (CNS)-specific antigen expressed on the myelin surface, is able to induce a paralytic MS-like disease with extensive CNS inflammation and demyelination in several strains of ...
متن کاملGranulocyte-Macrophage Colony-stimulating Factor
We show that 1,25-dihydroxyvitamin D3 (1,25[0H12D3), the most hormonally active metabolite of vitamin 113, modulates sensitively and specifically both the protein and messenger RNA accumulation of the multilineage growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF). The regulation of GMCSF expression is seen in both normal human mitogen-activated T lymphocytes and T lymphocy...
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A b stract P urp ose: T o imp rov e the ef f ectiv enes s of g ranu locy te colony -s timu lating f actor ( G -C SF ) treatment in hig h-ris k neu trop enic p atients . E x p erimental D esign: W e s tu dy G -C SF ef f ects on chemotherap y -indu ced neu trop enia b y ex p anding a s imp le mathematical model of neu trop hil dy namics in the b lood. T he f inal model is f itted and v alidated u...
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ژورنال
عنوان ژورنال: Neurosurgery
سال: 2012
ISSN: 0148-396X
DOI: 10.1227/01.neu.0000423046.04936.dc